How to filter protein annotations in UniProt?

Access the UniProt Website

• Open your web browser and go to the official UniProt website at https://www.uniprot.org.

 

• Ensure you have a stable internet connection for a seamless browsing and filtering experience.

Navigate to the Search Interface

• On the UniProt homepage, locate the search bar prominently displayed at the top of the page.

 

• Click on the Advanced Search link beneath the search bar for more nuanced filtering options.

Specify Protein Annotations

• Within the advanced search interface, locate the filters related to protein annotations such as "Function", "Subcellular Location", or "Pathology & BioTech".

 

• Select the desired annotation category by checking the specific boxes provided.

Apply Additional Filters

• You can narrow down your search further by applying additional filters such as "Reviewed" for Swiss-Prot entries or "Unreviewed" for TrEMBL entries.

 

• Utilize additional parameters like organism, sequence length, or keywords to fine-tune your search results.

Execute the Search

• After setting your desired filters, click the Search button to execute your query.

 

• Review the results page to ensure the search parameters have effectively filtered the protein annotations you are interested in.

Review and Export Results

• Examine the list of proteins provided and click on individual entries for detailed information.

 

• For offline analysis, you can export the filtered data by choosing the Download option, selecting your preferred format (e.g., XML, CSV, or plain text).

Refine Your Search

• If the results aren’t as expected, adjust your filters and search terms to refine your search.

 

• Bear in mind that the relevancy of the annotations might depend on the specificity of your search criteria.